Brunangelo Falini Selected Research

Nucleophosmin

12/2021	Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML.
1/2021	How I diagnose and treat NPM1-mutated AML.
1/2021	A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML).
10/2018	Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates.
5/2015	Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
5/2013	Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.
11/2011	Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy?
10/2011	High CD33 expression levels in acute myeloid leukemia cells carrying the nucleophosmin (NPM1) mutation.
1/2011	Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
11/2010	Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA.

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Brunangelo Falini Research Topics

Disease

41	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2021 - 01/2005
33	Neoplasms (Cancer) 01/2022 - 01/2002
17	Leukemia 10/2021 - 01/2002
13	Lymphoma (Lymphomas) 12/2020 - 01/2002
10	Hairy Cell Leukemia 01/2022 - 01/2004
8	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2016 - 03/2002
5	Residual Neoplasm 06/2015 - 08/2005
4	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2017 - 04/2003
4	B-Cell Lymphoma (Lymphoma, B Cell) 08/2004 - 12/2002
3	Infections 01/2022 - 09/2011
3	Hematologic Neoplasms (Hematological Malignancy) 12/2021 - 04/2007
3	Graft vs Host Disease (Graft-Versus-Host Disease) 09/2021 - 09/2002
3	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 12/2020 - 01/2002
3	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 03/2005 - 01/2002
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 12/2020 - 01/2002
2	Disease Progression 01/2019 - 03/2017
2	Hodgkin Disease (Hodgkin's Disease) 01/2017 - 08/2004
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2011 - 04/2002
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2009 - 02/2009
1	Candidiasis (Moniliasis) 09/2021
1	Candidemia 09/2021
1	Invasive Candidiasis 09/2021
1	Bacterial Infections (Bacterial Infection) 09/2021
1	Fever (Fevers) 09/2021
1	COVID-19 01/2021
1	Epstein-Barr Virus Infections 12/2020
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 10/2019
1	Bone Marrow Failure Disorders 10/2019
1	Hyperthermia 09/2017
1	Necrosis 09/2017
1	Multiple Myeloma 01/2017
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2016
1	Arthritis (Polyarthritis) 10/2015
1	Exanthema (Rash) 10/2015
1	Arthralgia (Joint Pain) 10/2015

Drug/Important Bio-Agent (IBA)

36	NucleophosminIBA 12/2021 - 03/2002
17	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2002
13	Biological ProductsIBA 01/2022 - 01/2004
5	purineIBA 01/2022 - 01/2012
5	Anaplastic Lymphoma KinaseIBA 01/2016 - 01/2002
4	Phosphotransferases (Kinase)IBA 01/2021 - 02/2009
4	DNA (Deoxyribonucleic Acid)IBA 03/2014 - 01/2005
4	AntibodiesIBA 10/2011 - 01/2002
3	Rituximab (Mabthera)FDA Link 01/2022 - 07/2004
3	Nuclear Export Signals (Nuclear Export Signal)IBA 12/2021 - 07/2007
3	AntigensIBA 01/2019 - 12/2010
3	Monoclonal AntibodiesIBA 11/2012 - 10/2004
3	Immunoglobulins (Immunoglobulin)IBA 11/2012 - 01/2002
2	VemurafenibIBA 01/2021 - 10/2015
2	Messenger RNA (mRNA)IBA 12/2020 - 01/2002
2	MicroRNAs (MicroRNA)IBA 12/2020 - 03/2008
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2019 - 12/2016
2	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 01/2019 - 03/2014
2	Biomarkers (Surrogate Marker)IBA 10/2017 - 01/2016
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2016 - 05/2015
2	Cyclin D1IBA 02/2014 - 01/2002
2	PhosphoproteinsIBA 04/2010 - 10/2005
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2009 - 02/2009
2	PAX5 Transcription FactorIBA 10/2004 - 01/2002
2	Transcription Factors (Transcription Factor)IBA 01/2003 - 01/2003
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 03/2002 - 01/2002
1	Cladribine FDA LinkGeneric 01/2022
1	Protein CIBA 12/2021
1	Tryptophan (L-Tryptophan)FDA Link 12/2021
1	dabrafenibIBA 11/2021
1	ChromatinIBA 10/2021
1	Rifaximin (L 105)FDA Link 09/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2021
1	Micafungin (FK463)FDA Link 09/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021
1	Nucleic AcidsIBA 12/2020
1	EnzymesIBA 10/2020
1	Immune Checkpoint InhibitorsIBA 12/2019
1	Small Nucleolar RNA (snoRNA)IBA 10/2019
1	Ribosomal RNAIBA 10/2019
1	Staphylococcal Protein A (Protein A)IBA 01/2019
1	Peptides (Polypeptides)IBA 01/2019
1	Decitabine FDA Link 01/2019
1	Etoposide (VP 16)FDA LinkGeneric 01/2019
1	IceIBA 01/2019
1	Long Noncoding RNAIBA 10/2017
1	Insulin-Like Growth Factor Binding Protein 6IBA 09/2017
1	Conditioned Culture MediaIBA 09/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	Imatinib Mesylate (Gleevec)FDA Link 12/2016
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2016
1	Protein Tyrosine PhosphatasesIBA 01/2016
1	Pharmaceutical PreparationsIBA 10/2015
1	Dactinomycin (Actinomycin)FDA LinkGeneric 09/2015
1	Arsenic Trioxide (Trisenox)FDA Link 05/2015

Therapy/Procedure

11	Drug Therapy (Chemotherapy) 01/2022 - 12/2002
11	Therapeutics 12/2021 - 01/2003
3	Haploidentical Transplantation 07/2014 - 09/2011
2	Hematopoietic Stem Cell Transplantation 09/2021 - 01/2021
2	Radiotherapy 01/2003 - 12/2002
1	Cell Transplantation 09/2021
1	Immunotherapy 01/2019
1	Heterologous Transplantation (Xenotransplantation) 01/2019
1	Drug Tapering 10/2015
1	Aftercare (After-Treatment) 10/2015